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They mimic the action of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which plays a crucial role in regulating blood sugar levels and appetite
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Mechanism: Stimulates GLP-1 and GIP receptors to enhance insulin secretion and satiety, while glucagon receptor activity increases energy expenditure
2016;311(5):E80317
The CREDENCE trial enrolled 4,401 participants with type 2 diabetes mellitus and CKD, with a mean eGFR of 56.2 mL/min/1.73 m 2 and a median urinary albumin-to-creatinine ratio (UACR) of 927 mg/g (Table 1, Fig
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